Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940686 | 0.87 | HTR2C (0.39) | ALDH1A1LMNASMN1; SMN2MAPTHPGD | |
| SCHEMBL1750940 | 0.72 | CYP2A6 (0.49) | CYP2A6ALDH1A1LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL17811701 | 0.68 | CYP11B1 (0.52) | CYP2A6ALDH1A1LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL29859251 | 0.67 | LMNA (0.61) | CYP2A6ALDH1A1LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL8016565 | 0.67 | CYP2A6 (0.65) | CYP2A6ALDH1A1LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL5032444 | 0.66 | SMN1; SMN2 (0.73) | CYP2A6ALDH1A1LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL29543568 | 0.66 | SMN1; SMN2 (0.73) | CYP2A6ALDH1A1LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL4631413 | 0.65 | CYP2A6 (0.62) | CYP2A6ALDH1A1LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL29933915 | 0.65 | CYP2A6 (0.62) | CYP2A6ALDH1A1LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL2100709 | 0.64 | CYP2A6 (1.00) | CYP2A6ALDH1A1LMNAHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | disclosed |
| US-20140315911-A1 | DIHYDROPTERIDINONES | OSI Pharmaceuticals, LLC | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315911-A1 | DIHYDROPTERIDINONES | DHPS, DHODH, HYPK | CYP2A6 646/4885ALDH1A1 1118/4885LMNA 4024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.