Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGDS | O60760 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16178673 | 0.87 | CYP2A6 (0.45) | SMN1; SMN2MAPTALDH1A1HPGDSLMNA | |
| SCHEMBL14940842 | 0.71 | — | — | |
| SCHEMBL1750073 | 0.69 | NPC1 (0.42) | HTR2CNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL379881 | 0.68 | SORD (0.33) | — | |
| SCHEMBL24787166 | 0.67 | HTR2C (0.47) | HTR2CNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL5804166 | 0.67 | CYP11B1 (0.42) | HTR2CNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL5332952 | 0.65 | GRM5 (0.48) | HTR2CNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL17318021 | 0.62 | KDR (0.59) | HTR2CNPC1RAB9ASMN1; SMN2NFKB1 | |
| Hydrochloric Acid SCHEMBL6470320 | 0.62 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL30379241 | 0.62 | KDM4E (0.49) | NPC1SMN1; SMN2MAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | disclosed |
| US-20140315911-A1 | DIHYDROPTERIDINONES | OSI Pharmaceuticals, LLC | 2014-10-23 | — | — | US | disclosed |
| EP-2776444-A1 | DIHYDROPTERIDINONES | OSI Pharmaceuticals, LLC (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013071217-A1 | DIHYDROPTERIDINONES | OSI Pharmaceuticals, LLC (US) | 2013-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315911-A1 | DIHYDROPTERIDINONES | DHPS, DHODH, HYPK | HTR2C 4096/4885NPC1 556/4885RAB9A 1497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.