Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17583600 | 0.88 | RXRA (0.55) | RXRARXRBFGFR1FGFR2FGFR3 | |
| SCHEMBL16180014 | 0.85 | CHEK1 (0.44) | CYP11B1CYP11B2CDK8MAOAMAOB | |
| SCHEMBL16180062 | 0.84 | CYP11B1 (0.53) | CYP11B1CYP11B2CDK8TDP1CA12 | |
| SCHEMBL30423385 | 0.79 | CYP11B1 (0.59) | CYP11B1CYP11B2CYP19A1RXRARXRB | |
| SCHEMBL29432706 | 0.78 | MAOA (0.62) | MAOAMAOBKDM4ETDP1ALDH1A1 | |
| SCHEMBL493931 | 0.78 | MAOA (0.62) | MAOAMAOBKDM4ETDP1ALDH1A1 | |
| SCHEMBL24619989 | 0.78 | CYP11B1 (0.44) | CYP11B1CYP11B2PRMT5WDR77S1PR1 | |
| SCHEMBL17687954 | 0.78 | PIK3CG (0.42) | CDK8PIK3CGALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL17157579 | 0.78 | RXRA (0.61) | RXRARXRBFGFR1FGFR2FGFR3 | |
| SCHEMBL3884124 | 0.77 | CHRNB2 (0.55) | CYP11B1CYP11B2KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2986607-B1 | ANTIBACTERIAL BIAROMATIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2017-06-14 | — | — | EP | disclosed |
| US-9527867-B2 | Antibacterial biaromatic derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-12-27 | — | — | US | disclosed |
| US-20160075722-A1 | Antibacterial Biaromatic Derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2016-03-17 | — | — | US | disclosed |
| EP-2986607-A1 | ANTIBACTERIAL BIAROMATIC DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2016-02-24 | — | — | EP | disclosed |
| WO-2014170821-A1 | ANTIBACTERIAL BIAROMATIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2014-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075722-A1 | Antibacterial Biaromatic Derivatives | CYC1, C5, CYCS | CYP11B1 1466/4885CYP11B2 2221/4885CYP19A1 1995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.