Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364672 | 0.82 | ESR1 (0.53) | ESR1ESR2MAPTHTTKDM4E | |
| SCHEMBL28074378 | 0.74 | GAA (0.35) | MAPTHTT | |
| Alcohol SCHEMBL27829553 | 0.72 | — | — | |
| SCHEMBL3849718 | 0.68 | CA3 (0.52) | ESR1ESR2MAPTHTTKDM4E | |
| SCHEMBL8370360 | 0.68 | HSD17B1 (0.64) | ESR1ESR2MAPTHTTKDM4E | |
| SCHEMBL13625815 | 0.68 | HMGCR (0.55) | ESR1ESR2MAPTLMNABACE1 | |
| SCHEMBL13652987 | 0.67 | TTR (0.60) | ESR1ESR2MAPTHTTKDM4E | |
| SCHEMBL1616373 | 0.66 | HIF1A (0.54) | MAPTHTTLMNAALOX15HSD17B10 | |
| SCHEMBL4814741 | 0.66 | MAPT (0.47) | MAPTHTTKDM4ELMNATP53 | |
| SCHEMBL27884951 | 0.66 | ANO1 (0.43) | ESR1ESR2MAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014170793-A1 | SULFONAMIDES FOR THE TREATMENT OF GOUT | PFIZER LIMITED (GB) | 2014-10-23 | — | — | WO | disclosed |