Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 3/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL35778 | 0.97 | ALOX12 (0.47) | ALOX12CYP2A6SMN1; SMN2TSHRLMNA | |
| Naphthalene SCHEMBL672294 | 0.94 | ALOX12 (0.57) | ALOX12CYP2A6SMN1; SMN2TSHRLMNA | |
| Naphthalene SCHEMBL2678900 | 0.94 | ALOX12 (0.57) | ALOX12CYP2A6SMN1; SMN2TSHRLMNA | |
| Naphthalene SCHEMBL29361795 | 0.94 | ALOX12 (0.57) | ALOX12CYP2A6SMN1; SMN2TSHRLMNA | |
| Naphthalene SCHEMBL5574575 | 0.94 | ALOX12 (0.57) | ALOX12CYP2A6SMN1; SMN2TSHRLMNA | |
| Naphthalene SCHEMBL28674544 | 0.94 | ALOX12 (0.57) | ALOX12CYP2A6SMN1; SMN2TSHRLMNA | |
| Naphthalene SCHEMBL27964063 | 0.91 | ALOX12 (0.47) | ALOX12CYP2A6SMN1; SMN2TSHRLMNA | |
| Naphthalene SCHEMBL9484717 | 0.90 | ALOX12 (0.53) | ALOX12CYP2A6SMN1; SMN2TSHRLMNA | |
| Naphthalene SCHEMBL28983768 | 0.90 | ALOX12 (0.53) | ALOX12CYP2A6SMN1; SMN2TSHRLMNA | |
| Naphthalene SCHEMBL8773082 | 0.90 | ALOX12 (0.53) | ALOX12CYP2A6SMN1; SMN2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112551537-A | Method and device for obtaining valuable substances from bauxite residues | 欧洲大西洋资本有限责任公司 | 2021-03-26 | — | — | CN | disclosed |
| EP-1758833-B1 | IMPROVING THE FREEZE-THAW DURABILITY OF DRY CAST CEMENTITIOUS MIXTURES | CONSTR RES & TECH GMBH (DE) | 2016-06-01 | — | — | EP | disclosed |
| US-8216719-B2 | Non-aqueous secondary battery and method for producing the same | HITACHI MAXELL ENERGY, LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| CN-1829441-B | Liquid formulation | BAYER CROPSCIENCE GMBH | 2011-10-19 | — | — | CN | disclosed |
| US-7922808-B2 | Freeze-thaw durability of dry cast cementitious mixtures | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2011-04-12 | — | — | US | disclosed |
| US-7678326-B2 | Method and apparatus for manufacturing fine particles | KABUSHIKI KAISHA TOSHIBA (JP) | 2010-03-16 | — | — | US | disclosed |
| EP-1394621-B1 | Dry two-component type developer for electrophotography | POWDERTECH CO LTD (JP) | 2008-05-21 | — | — | EP | disclosed |
| US-7297323-B2 | Method and apparatus for manufacturing fine particles | KABUSHIKI KAISHA TOSHIBA (JP) | 2007-11-20 | — | — | US | disclosed |
| US-20070246868-A1 | METHOD AND APPARATUS FOR MANUFACTURING FINE PARTICLES | KABUSHIKI KAISHA TOSHIBA (JP) | 2007-10-25 | — | — | US | disclosed |
| EP-1839055-A2 | ASSAY METHOD AND APPARATUS WITH REDUCED SAMPLE MATRIX EFFECTS | BioVeris Corporation (US) | 2007-10-03 | — | — | EP | disclosed |
| US-20050274294-A1 | Freeze-thaw durability of dry cast cementitious mixtures | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2005-12-15 | — | — | US | disclosed |
| US-6905806-B2 | Dry two-component type developer for electrophotography | POWDERTECH CO., LTD. (JP) | 2005-06-14 | — | — | US | disclosed |
| US-20040043320-A1 | Dry two-component type developer for electrophotography | POWDERTECH CO., LTD. | 2004-03-04 | — | — | US | disclosed |
| EP-1394621-A2 | Dry two-component type developer for electrophotography | POWDERTECH CO. LTD. (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-0997514-B1 | Rosin containing emulsion for pressure-sensitive adhesive | NIPPON CATALYTIC CHEM IND (JP) | 2003-07-30 | — | — | EP | disclosed |
| US-20030059354-A1 | Method and apparatus for manufacturing fine particles | KABUSHIKI KAISHA TOSHIBA (JP) | 2003-03-27 | — | — | US | disclosed |
| US-6518342-B1 | Exhibits high adhesive strength to hard-to-adhere adherend such as polyolefin, high resistance to water, and high cohesive strength | NIPPON SHOKUBAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |
| EP-0997514-A1 | Rosin containing emulsion for pressure-sensitive adhesive | NIPPON SHOKUBAI CO., LTD. (JP) | 2000-05-03 | — | — | EP | disclosed |
| US-5556510-A | PURIFICATION OF PULP USING DETACKIFIER OF CATIONIC STARCH AND ANIONIC SURFACTANT WITH MALEIC ANHYDRIDE COPOLYMERS | BETZ LABORATORIES, INC. (US) | 1996-09-17 | — | — | US | disclosed |
| EP-0014326-A1 | Dye composition and its use for dyeing and printing cellulose fibers | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-08-20 | — | — | EP | disclosed |