Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16183411 | 0.91 | CYP11B2 (0.42) | SRD5A1CYP11B2CYP11B1GBA1HTR2A | |
| SCHEMBL16183412 | 0.89 | CYP11B2 (0.41) | SRD5A1CYP11B2CYP11B1GBA1HTR2A | |
| SCHEMBL16183415 | 0.86 | CYP11B2 (0.41) | SRD5A1CYP11B2CYP11B1GBA1HTR2A | |
| SCHEMBL16183414 | 0.86 | CYP11B2 (0.38) | SRD5A1CYP11B2CYP11B1GBA1HTR2A | |
| SCHEMBL16183413 | 0.86 | CYP11B2 (0.40) | SRD5A1CYP11B2CYP11B1GBA1HTR2A | |
| SCHEMBL16183417 | 0.84 | GBA1 (0.42) | SRD5A1CYP11B2CYP11B1GBA1HTR2A | |
| SCHEMBL14475928 | 0.83 | GBA1 (0.46) | CYP11B2CYP11B1GBA1HTR2AHTR2C | |
| SCHEMBL16183995 | 0.82 | ALDH1A1 (0.45) | SRD5A1CYP11B2CYP11B1GBA1HTR2A | |
| SCHEMBL14474807 | 0.82 | GBA1 (0.49) | CYP11B2CYP11B1GBA1HTR2AHTR2C | |
| SCHEMBL16183373 | 0.81 | GBA1 (0.46) | CYP11B2CYP11B1GBA1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP2CA, PPP4C, PPP3CB | SRD5A1 2215/4885CYP11B2 2204/4885CYP11B1 2235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.