Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | PNMT | P11086 | 7/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28876770 | 0.81 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL28284898 | 0.81 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL9818948 | 0.80 | PBRM1 (0.60) | TDP1PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL28016153 | 0.78 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL12227742 | 0.78 | ALDH1A1 (0.42) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL8035992 | 0.78 | PNMT (0.45) | TDP1PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL14421919 | 0.77 | PNMT (0.42) | TDP1PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL14780632 | 0.77 | MEN1 (0.43) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL13712678 | 0.77 | AKR1B1 (0.43) | TDP1PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL8118210 | 0.76 | CHRNB4 (0.57) | TDP1PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105026392-B | 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof | 四川海思科制药有限公司 | 2017-05-10 | — | — | CN | disclosed |
| WO-2014169845-A2 | 4,5-DIHYDRO-PYRAZOLO [3, 4-C] PYRID-2-ONES, PREPARATION METHOD AND APPLICATION THEREOF | 四川海思科制药有限公司 (CN) | 2014-10-23 | — | — | WO | disclosed |
| CN-104109165-A | 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives, and preparation method and application thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2014-10-22 | — | — | CN | disclosed |