Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 6/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426345 | 0.83 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL16190023 | 0.78 | TDP1 (0.53) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL8042044 | 0.76 | AKT1 (0.35) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL8039833 | 0.75 | PNMT (0.39) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL28284898 | 0.75 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL28876770 | 0.75 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL8428902 | 0.73 | PNMT (0.38) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL28016153 | 0.72 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL12227742 | 0.72 | ALDH1A1 (0.42) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL9571097 | 0.72 | PNMT (0.45) | PNMTADRA2AADRA2BADRA2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000076990-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |