Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 7/20 | 0.45 |
| ▸ | CA12 | O43570 | 6/20 | 0.45 |
| ▸ | CA1 | P00915 | 6/20 | 0.45 |
| ▸ | CA9 | Q16790 | 6/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749667 | 0.87 | MEN1 (0.77) | MEN1KMT2AGAAMAOAMAOB | |
| SCHEMBL18704730 | 0.87 | MEN1 (0.77) | MEN1KMT2AGAAMAOAMAOB | |
| SCHEMBL13694012 | 0.85 | MEN1 (0.84) | MEN1KMT2AGAAMAOAMAOB | |
| SCHEMBL4755749 | 0.83 | MEN1 (0.60) | MEN1KMT2AGAAMAOAMAOB | |
| SCHEMBL12901343 | 0.83 | MEN1 (0.60) | MEN1KMT2AGAAMAOAMAOB | |
| SCHEMBL25407355 | 0.83 | MEN1 (0.60) | MEN1KMT2AGAAMAOAMAOB | |
| SCHEMBL16925627 | 0.80 | MAOA (0.60) | MEN1KMT2AGAAMAOAMAOB | |
| SCHEMBL12341083 | 0.80 | MEN1 (0.71) | MEN1KMT2AGAAMAOAMAOB | |
| SCHEMBL15376152 | 0.80 | MEN1 (0.71) | MEN1KMT2AGAAMAOAMAOB | |
| SCHEMBL25501121 | 0.79 | MEN1 (0.79) | MEN1KMT2AGAAMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134125-A1 | ANTIBODY-DRUG-CONJUGATE AND ITS USE FOR THE TREATMENT OF CANCER | Pierre Fabre Médicament (FR) | 2017-03-01 | — | — | EP | disclosed |
| EP-2989087-A1 | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS | Pierre Fabre Médicament (FR) | 2016-03-02 | — | — | EP | disclosed |
| WO-2015162293-A1 | ANTIBODY-DRUG-CONJUGATE AND ITS USE FOR THE TREATMENT OF CANCER | PIERRE FABRE MEDICAMENT (FR) | 2015-10-29 | — | — | WO | disclosed |
| WO-2014174062-A1 | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS | PIERRE FABRE MEDICAMENT (FR) | 2014-10-30 | — | — | WO | disclosed |