Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31617333 | 0.82 | HSD17B10 (0.45) | DYRK1ACLK4NR1H2NR1H3KMT2A | |
| SCHEMBL14996631 | 0.81 | MEN1 (0.43) | KMT2ALMNAKDM4EMAPTHPGD | |
| SCHEMBL14139215 | 0.79 | ALDH1A1 (0.46) | DYRK1ACLK4NR1H2NR1H3HSD17B10 | |
| SCHEMBL16200060 | 0.77 | THRB (0.52) | NR1H2NR1H3KMT2AHSD17B10LMNA | |
| SCHEMBL16381210 | 0.76 | MAPK14 (0.49) | DYRK1ACLK4NR1H2NR1H3KMT2A | |
| SCHEMBL15331791 | 0.75 | CYP1A2 (0.46) | DYRK1ACLK4KMT2AHSD17B10LMNA | |
| SCHEMBL13739588 | 0.74 | PDE10A (0.45) | KMT2AHSD17B10LMNATSHRMAPK1 | |
| SCHEMBL13739273 | 0.73 | PDE10A (0.44) | LMNATSHRMAPK1MAPTTP53 | |
| SCHEMBL15885364 | 0.72 | L3MBTL1 (0.46) | DYRK1ACLK4KMT2AHSD17B10LMNA | |
| SCHEMBL13024563 | 0.72 | GAA (0.55) | DYRK1ACLK4NR1H2NR1H3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |