Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178795 | 0.83 | P2RX3 (0.39) | ALDH1A1GAALMNATAAR1NPC1 | |
| SCHEMBL13178806 | 0.81 | SLC6A4 (0.48) | MAPTSMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL16200298 | 0.79 | ALDH1A1 (0.47) | MAPTSMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL14582024 | 0.77 | MAPT (0.42) | MAPTSMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL14582026 | 0.77 | TAAR1 (0.46) | MAPTSMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL16200315 | 0.76 | KMT2A (0.58) | MAPTALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL12467312 | 0.75 | TAAR1 (0.46) | MAPTSMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL16200300 | 0.75 | MTNR1A (0.48) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL14582025 | 0.75 | MAPT (0.43) | MAPTSMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL19195019 | 0.74 | TAAR1 (0.44) | MAPTSMN1; SMN2ALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |