Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28754536 | 0.91 | HRH3 (0.58) | HRH3L3MBTL1CCR8HTR4CHRM1 | |
| SCHEMBL21341791 | 0.85 | HRH3 (0.40) | HRH3L3MBTL1CCR8HTR4ACKR3 | |
| SCHEMBL21472208 | 0.85 | HRH3 (0.40) | HRH3L3MBTL1CCR8HTR4ACKR3 | |
| SCHEMBL25389091 | 0.84 | KDM1A (0.47) | L3MBTL1HTR4ACKR3KDM4EKMT2A | |
| SCHEMBL12332732 | 0.84 | LTA4H (0.54) | HTR4ACKR3CHRM1KDM4EKMT2A | |
| SCHEMBL24744482 | 0.83 | L3MBTL1 (0.62) | HRH3L3MBTL1CCR8CHRM1KDM4E | |
| SCHEMBL17513083 | 0.83 | SMN1; SMN2 (0.57) | HRH3L3MBTL1CCR8CHRM1SIGMAR1 | |
| SCHEMBL27517725 | 0.83 | LTA4H (0.53) | HTR4ACKR3KDM4EKMT2AMEN1 | |
| SCHEMBL23711916 | 0.82 | L3MBTL1 (0.50) | HRH3L3MBTL1CCR8HTR4CHRM1 | |
| SCHEMBL12304479 | 0.80 | HTR4 (0.49) | HTR4ACKR3CHRM1KDM4EKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483249-B1 | PYRIMIDINE DERIVATIVES AS PROTEIN TYROSINE KINASE 2 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |
| EP-2408752-B1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2015-08-12 | — | — | EP | disclosed |
| EP-2435411-B1 | 2,4-DIAMINOPYRIMIDINES FOR THE TREATMENT OF DISEASES CHARACTERISED BY EXCESSIVE OR ABNORMAL CELL PROLIFERATION | BOEHRINGER INGELHEIM INT (DE) | 2014-10-29 | — | — | EP | disclosed |