Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25784228 | 0.89 | DPP4 (0.35) | DPP4 | |
| SCHEMBL12090756 | 0.84 | HSD11B1 (0.37) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL24577501 | 0.84 | DPP4 (0.56) | DPP4BTKMEN1KMT2AALDH1A1 | |
| SCHEMBL8707506 | 0.83 | DPP4 (0.38) | DPP4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10313873 | 0.81 | PDK2 (0.36) | HPGDCCR5HSD11B1 | |
| SCHEMBL22711094 | 0.81 | NR1H2 (0.43) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL28465532 | 0.81 | HSD11B1 (0.36) | MEN1KMT2AALDH1A1MAPTCCR5 | |
| SCHEMBL27510109 | 0.78 | EPHX1 (0.39) | DPP4HSD11B1EPHX1 | |
| SCHEMBL25032511 | 0.78 | ACHE (0.36) | DPP4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL23482261 | 0.77 | CTSS (0.34) | BTKMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150038482-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2015-02-05 | — | — | US | disclosed |
| US-20150038479-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2015-02-05 | — | — | US | disclosed |
| US-8927724-B2 | Isoxazole beta-lactamase inhibitors | CUBIST PHARMACEUTICALS, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| US-20140323459-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038482-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | ALPL, MGAM, PEPD | DPP4 218/4885BTK 834/4885MEN1 4087/4885 |
| US-20150038479-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | ALPL, MGAM, PEPD | DPP4 218/4885BTK 834/4885MEN1 4087/4885 |
| US-20140323459-A1 | ISOXAZOLE BETA-LACTAMASE INHIBITORS | ALPL, MGAM, PEPD | DPP4 218/4885BTK 834/4885MEN1 4087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.