Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 9/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17549580 | 0.77 | KDR (0.57) | KDRNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL17549579 | 0.74 | KDR (0.53) | KDRNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1984341 | 0.73 | SYK (0.68) | — | |
| SCHEMBL13994012 | 0.73 | CD38 (0.52) | CD38EGFRRETDYRK1ABRD4 | |
| SCHEMBL18936841 | 0.72 | MEN1 (0.53) | CD38KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28620448 | 0.72 | DYRK1A (0.46) | CD38KDRRETMAPTDYRK1A | |
| SCHEMBL48894 | 0.72 | DYRK1A (0.55) | CD38KDRNPC1SMN1; SMN2MAPT | |
| SCHEMBL13996617 | 0.71 | CD38 (0.53) | CD38EGFRRETDYRK1ABRD4 | |
| SCHEMBL19219055 | 0.71 | PIM1 (0.51) | CD38NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1062981 | 0.71 | MEN1 (0.50) | KDREGFRNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014176210-A1 | THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-10-30 | — | — | WO | disclosed |