Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | CD38 | P28907 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MECP2 | P51608 | 1/20 | 0.38 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17102743 | 0.73 | MEN1 (0.66) | MEN1KMT2AMAPK10GFERNPC1 | |
| SCHEMBL16205256 | 0.72 | CD38 (0.60) | MEN1KMT2ACD38NPC1RAB9A | |
| SCHEMBL20455525 | 0.72 | CDK4 (0.49) | MEN1KMT2ACD38NPC1RAB9A | |
| SCHEMBL29386286 | 0.72 | CDK4 (0.49) | MEN1KMT2ACD38NPC1RAB9A | |
| SCHEMBL3279571 | 0.72 | MEN1 (1.00) | MEN1KMT2AMAPK10GFERNPC1 | |
| SCHEMBL24568619 | 0.70 | CYP2A6 (0.51) | CD38NPC1KDRPIM1 | |
| SCHEMBL30482452 | 0.70 | PIM1 (0.45) | CD38PIM1 | |
| SCHEMBL27164862 | 0.70 | PIM1 (0.45) | CD38PIM1 | |
| SCHEMBL2513836 | 0.68 | PIM1 (0.58) | CD38NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL24567811 | 0.67 | TBXAS1 (0.41) | CD38RAB9ASMN1; SMN2PIM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2706853-B1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-06-14 | — | — | EP | disclosed |