Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.55 |
| ▸ | TNKS | O95271 | 6/20 | 0.55 |
| ▸ | PARP1 | P09874 | 5/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.55 |
| ▸ | WNT3A | P56704 | 4/20 | 0.55 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.55 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.55 |
| ▸ | AXIN2 | Q9Y2T1 | 1/20 | 0.55 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15315468 | 0.78 | TNKS2 (0.56) | TNKS2TNKSPARP1PARP2WNT3A | |
| SCHEMBL29411302 | 0.78 | TNKS2 (0.56) | TNKS2TNKSPARP1PARP2WNT3A | |
| SCHEMBL7783488 | 0.71 | TNKS2 (1.00) | TNKS2TNKSPARP1PARP2WNT3A | |
| SCHEMBL20286634 | 0.68 | TNKS2 (0.46) | TNKS2TNKSPARP1PARP2WNT3A | |
| SCHEMBL9171950 | 0.67 | TNKS (0.46) | TNKS2TNKSPARP1PARP2WNT3A | |
| SCHEMBL21097251 | 0.66 | TNKS2 (0.68) | TNKS2TNKSPARP1PARP2WNT3A | |
| SCHEMBL15565864 | 0.63 | TNKS2 (0.67) | TNKS2TNKSPARP1PARP2WNT3A | |
| SCHEMBL22321661 | 0.62 | KIF11 (0.50) | ADORA3IDO1TDO2TOP1KIF11 | |
| SCHEMBL1841140 | 0.61 | RAD51 (0.54) | ADORA3TOP1KIF11CTSSCTSK | |
| SCHEMBL22321627 | 0.60 | KIF11 (0.47) | ADORA3KIF11SNCAKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014176606-A1 | CORTICAL INTERNEURONS AND OTHER NEURONAL CELLS PRODUCED BY THE DIRECTED DIFFERENTIATION OF PLURIPOTENT AND MULTIPOTENT CELLS | MEMORIAL SLOAN-KETTERING CENTER CENTER (US) | 2014-10-30 | — | — | WO | disclosed |