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SCHEMBL16210779

SCHEMBL16210779

Cc1nc(Cl)cc(C2CCCN(C(=O)OC(C)(C)C)C2)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPV3 Q8NET8 2/20 0.46
▸ ALDH1A1 P00352 2/20 0.44
▸ KDM4E B2RXH2 1/20 0.44
▸ GLA P06280 1/20 0.44
▸ HPGD P15428 1/20 0.44
▸ RECQL P46063 1/20 0.44
▸ HSD17B10 Q99714 1/20 0.44
▸ HPGDS O60760 1/20 0.43
▸ GPR119 Q8TDV5 1/20 0.42
▸ PRMT5 O14744 1/20 0.42
▸ JAK2 O60674 1/20 0.42
▸ JAK1 P23458 1/20 0.42
▸ MAP3K12 Q12852 4/20 0.42
▸ MEN1 O00255 3/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ MAPT P10636 1/20 0.41
▸ USP30 Q70CQ3 1/20 0.41
▸ CNR1 P21554 1/20 0.40
▸ CNR2 P34972 1/20 0.40
▸ P2RX7 Q99572 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16220115 0.90 TRPV3 (0.46) TRPV3ALDH1A1KDM4EGLAHPGD
SCHEMBL21604683 0.88 ALDH1A1 (0.47) TRPV3ALDH1A1KDM4EGLAHPGD
SCHEMBL15641234 0.87 KDM4E (0.50) ALDH1A1KDM4EHPGDHSD17B10GPR119
SCHEMBL16220250 0.84 KDM4E (0.46) TRPV3ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL31224355 0.83 PDE4B (0.47) TRPV3ALDH1A1KDM4EGLAHPGD
SCHEMBL16211959 0.83 MAP3K12 (0.48) MAP3K12
SCHEMBL16220399 0.81 TRPV3 (0.41) TRPV3ALDH1A1KDM4EGLAHPGD
SCHEMBL31383603 0.81 TRPV3 (0.49) TRPV3ALDH1A1KDM4EGLAHPGD
SCHEMBL14991675 0.81 TRPV3 (0.46) TRPV3ALDH1A1KDM4EGLAHPGD
SCHEMBL17898211 0.81 TRPV3 (0.51) TRPV3ALDH1A1KDM4EGLAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2991978-B1 BIHETEROARYL COMPOUNDS AND USES THEREOF F HOFFMANN LA ROCHE SA (CH) 2025-08-20 — — EP disclosed
US-11129832-B2 Biheteroaryl compounds and uses thereof GENENTECH, INC. (US) 2021-09-28 — — US disclosed
US-20200188397-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2020-06-18 — — US disclosed
US-20200171029-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2020-06-04 — — US disclosed
US-RE47848-E1 Biheteroaryl compounds and uses thereof GENENTECH, INC. (US) 2020-02-11 — — US disclosed
US-10028954-B2 Biheteroaryl compounds and uses thereof GENENTECH, INC. (US) 2018-07-24 — — US disclosed
US-10010549-B2 Biheteroaryl compounds and uses thereof GENENTECH, INC. (US) 2018-07-03 — — US disclosed
US-20180133219-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2018-05-17 — — US disclosed
US-20180117044-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2018-05-03 — — US disclosed
US-20170239246-A9 BIHETEROARYL COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2017-08-24 — — US disclosed
US-20160158234-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2016-06-09 — — US disclosed
US-20160052940-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2016-02-25 — — US disclosed
US-9266862-B2 Biheteroaryl compounds and uses thereof GENENTECH, INC. (US) 2016-02-23 — — US disclosed
US-20140328805-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF GENENTECH, INC. (US) 2014-11-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170239246-A9 BIHETEROARYL COMPOUNDS AND USES THEREOF BCHE, SNCA, XDH TRPV3 1490/4885ALDH1A1 903/4885KDM4E 3228/4885
US-20180117044-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF BCHE, SNCA, XDH TRPV3 1490/4885ALDH1A1 903/4885KDM4E 3228/4885
US-10010549-B2 Biheteroaryl compounds and uses thereof BCHE, SNCA, HAX1 TRPV3 1746/4885ALDH1A1 950/4885KDM4E 3436/4885
US-11129832-B2 Biheteroaryl compounds and uses thereof BCHE, SNCA, HAX1 TRPV3 1746/4885ALDH1A1 950/4885KDM4E 3436/4885
US-20200171029-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF BCHE, SNCA, XDH TRPV3 1490/4885ALDH1A1 903/4885KDM4E 3228/4885
US-20160158234-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF BCHE, SNCA, XDH TRPV3 1490/4885ALDH1A1 903/4885KDM4E 3228/4885
US-10028954-B2 Biheteroaryl compounds and uses thereof BCHE, SNCA, XDH TRPV3 1490/4885ALDH1A1 903/4885KDM4E 3228/4885
US-20180133219-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF BCHE, SNCA, HAX1 TRPV3 1746/4885ALDH1A1 950/4885KDM4E 3436/4885
US-20160052940-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF BCHE, SNCA, HAX1 TRPV3 1746/4885ALDH1A1 950/4885KDM4E 3436/4885
US-20140328805-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF BCHE, SNCA, XDH TRPV3 1490/4885ALDH1A1 903/4885KDM4E 3228/4885
US-20200188397-A1 BIHETEROARYL COMPOUNDS AND USES THEREOF BCHE, SNCA, HAX1 TRPV3 1746/4885ALDH1A1 950/4885KDM4E 3436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.