Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | GFER | P55789 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DEPTOR | Q8TB45 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 2/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901064 | 0.92 | ALDH1A1 (0.41) | ALDH1A1GFERGAAMAPTTDP1 | |
| Sulfuric Acid SCHEMBL8745492 | 0.66 | ACP1 (0.44) | ALDH1A1GFERGAAMAPTTDP1 | |
| SCHEMBL6977827 | 0.63 | DEPTOR (0.53) | ALDH1A1GFERGAAMAPTTDP1 | |
| SCHEMBL9841099 | 0.62 | ACP1 (0.44) | ALDH1A1GAAMAPTTDP1NPC1 | |
| SCHEMBL5360504 | 0.62 | NOX1 (0.48) | ALDH1A1GFERGAAMAPTTDP1 | |
| Diphenylamine SCHEMBL1008716 | 0.61 | HSD17B10 (0.67) | ALDH1A1GFERGAAMAPTTDP1 | |
| Diphenylamine SCHEMBL28015233 | 0.61 | HSD17B10 (0.67) | ALDH1A1GFERGAAMAPTTDP1 | |
| Diphenylamine SCHEMBL1008717 | 0.61 | HSD17B10 (0.67) | ALDH1A1GFERGAAMAPTTDP1 | |
| SCHEMBL14003218 | 0.61 | ALDH1A1 (0.43) | ALDH1A1GFERGAAMAPTTDP1 | |
| SCHEMBL27873782 | 0.60 | ALDH1A1 (0.54) | ALDH1A1GFERGAAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023180245-A1 | USE OF SHP2 INHIBITORS FOR INHIBITING SENESCENCE | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2023-09-28 | — | — | WO | disclosed |
| US-20220000869-A1 | USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE | UNIVERSITE PAUL SABATIER TOULOUSE III (FR) | 2022-01-06 | — | — | US | disclosed |
| EP-3883574-A1 | USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2021-09-29 | — | — | EP | disclosed |
| US-20160129021-A1 | STERILIZATION METHOD | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-05-12 | — | — | US | disclosed |
| WO-2014179095-A1 | STERILIZATION METHOD | UNIVERSITY OF PITTSBURGH- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160129021-A1 | STERILIZATION METHOD | PTPN1, PTPN5, PTPN2 | ALDH1A1 333/4885GFER 3496/4885GAA 1196/4885 |
| US-20220000869-A1 | USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE | PTPN1, PTPN7, PTPN21 | ALDH1A1 3823/4885GFER 2206/4885GAA 525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.