Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19720569 | 1.00 | SIGMAR1 (0.36) | SIGMAR1LTA4HHRH3CARM1PRMT6 | |
| SCHEMBL22972376 | 0.98 | SIGMAR1 (0.38) | SIGMAR1LTA4HHRH3CARM1PRMT6 | |
| SCHEMBL8520735 | 0.98 | SIGMAR1 (0.38) | SIGMAR1LTA4HHRH3CARM1PRMT6 | |
| Hydrochloric Acid SCHEMBL2704381 | 0.95 | SIGMAR1 (0.37) | SIGMAR1LTA4HHRH3CHRNB2CHRNB4 | |
| SCHEMBL9111540 | 0.78 | SIGMAR1 (0.38) | SIGMAR1LTA4HHRH3CARM1PRMT6 | |
| SCHEMBL9111537 | 0.78 | SIGMAR1 (0.38) | SIGMAR1LTA4HHRH3CARM1PRMT6 | |
| SCHEMBL23872300 | 0.78 | LTA4H (0.42) | SIGMAR1LTA4HHRH3CARM1PRMT6 | |
| SCHEMBL819102 | 0.76 | HRH3 (0.37) | SIGMAR1HRH3CARM1PRMT6PRMT8 | |
| SCHEMBL9112203 | 0.76 | SIGMAR1 (0.41) | SIGMAR1LTA4HHRH3CHRNB2CHRNB4 | |
| SCHEMBL9112196 | 0.76 | SIGMAR1 (0.41) | SIGMAR1LTA4HHRH3CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470012-B1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2014-11-05 | — | — | EP | disclosed |