Sugi Predict

Sugi Predict / Compounds / SCHEMBL1621674

SCHEMBL1621674

SCHEMBL1621674

Cc1ccccc1Cc1nc(Cl)c2c(n1)CCN(Cc1ccccc1)CC2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CLPP Q16740 8/20 0.48
▸ C5AR1 P21730 1/20 0.45
▸ KMT2A Q03164 2/20 0.43
▸ GAA P10253 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ GLA P06280 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ MEN1 O00255 1/20 0.42
▸ CYP3A4 P08684 2/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ HIF1A Q16665 1/20 0.40
▸ SIGMAR1 Q99720 1/20 0.40
▸ CYP2D6 P10635 1/20 0.40
▸ DRD2 P14416 1/20 0.40
▸ DRD3 P35462 1/20 0.40
▸ KCNH2 Q12809 1/20 0.40
▸ GPR132 Q9UNW8 1/20 0.40
▸ CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1623038 0.87 CLPP (0.49) CLPPC5AR1KMT2AGAAKDM4E
SCHEMBL1623121 0.87 KMT2A (0.49) CLPPC5AR1KMT2AGAAKDM4E
SCHEMBL1623057 0.85 LMNA (0.52) CLPPC5AR1KMT2AGAAKDM4E
SCHEMBL1623206 0.83 CLPP (0.47) CLPPC5AR1KMT2AGAAKDM4E
SCHEMBL1622745 0.82 SIGMAR1 (0.52) CLPPC5AR1KMT2AGAAKDM4E
SCHEMBL1623049 0.81 SIGMAR1 (0.53) CLPPC5AR1KMT2AGAAKDM4E
SCHEMBL1622535 0.81 HTR2A (0.50) CLPPC5AR1KMT2AGAAKDM4E
SCHEMBL1623084 0.80 C5AR1 (0.44) C5AR1KMT2AGAAKDM4EALDH1A1
SCHEMBL1622832 0.79 CLPP (0.47) CLPPC5AR1KMT2AGAAKDM4E
SCHEMBL1621143 0.78 C5AR1 (0.47) CLPPC5AR1KMT2AALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7928099-B2 Pyrimido [4,5-D] azepine derivatives as 5-HT2c agonists PFIZER INC (US) 2011-04-19 — — US disclosed
US-7928099-B2 Pyrimido [4,5-D] azepine derivatives as 5-HT2c agonists PFIZER INC (US) 2011-04-19 — — US disclosed
US-7928099-B2 Pyrimido [4,5-D] azepine derivatives as 5-HT2c agonists PFIZER INC (US) 2011-04-19 — — US disclosed
US-20100113422-A1 Pyrimido [4,5-D] Azepine Derivatives As 5-HT2C Agonists ANDREWS MARK 2010-05-06 — — US disclosed
US-20100113422-A1 Pyrimido [4,5-D] Azepine Derivatives As 5-HT2C Agonists ANDREWS MARK 2010-05-06 — — US disclosed
US-20100113422-A1 Pyrimido [4,5-D] Azepine Derivatives As 5-HT2C Agonists ANDREWS MARK 2010-05-06 — — US disclosed
WO-2008117169-A1 PYRIMIDO [4, 5-D] AZEPINE DERIVATIVES AS 5-HT2C AGONISTS PFIZER LIMITED (GB) 2008-10-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100113422-A1 Pyrimido [4,5-D] Azepine Derivatives As 5-HT2C Agonists HTR2C, HTR2A, HTR5A CLPP 4685/4885C5AR1 377/4885KMT2A 1526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.