Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | CPA1 | P15085 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13910050 | 1.00 | ACE (0.52) | ACEFOLH1CA12CA1CA9 | |
| SCHEMBL15095619 | 0.88 | ESR1 (0.53) | ACEFOLH1SLC7A5TAAR1NAALAD2 | |
| SCHEMBL15336553 | 0.88 | ESR1 (0.53) | ACEFOLH1SLC7A5TAAR1NAALAD2 | |
| SCHEMBL12118797 | 0.87 | ATM (0.44) | ACE | |
| SCHEMBL11409509 | 0.85 | ALDH1A1 (0.46) | ACECA12CA9 | |
| SCHEMBL30699914 | 0.85 | SIGMAR1 (0.53) | ACECA12CA1CA9SLC7A5 | |
| SCHEMBL547121 | 0.85 | FOLH1 (0.61) | ACEFOLH1SLC7A5NAALAD2MME | |
| SCHEMBL1287829 | 0.85 | FOLH1 (0.61) | ACEFOLH1SLC7A5NAALAD2MME | |
| SCHEMBL4672507 | 0.85 | SIGMAR1 (0.53) | ACECA12CA1CA9SLC7A5 | |
| SCHEMBL989835 | 0.85 | SIGMAR1 (0.53) | ACECA12CA1CA9SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014179620-A1 | CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE | ISIS PHARMACEUTICALS, INC. (US) | 2014-11-06 | — | — | WO | disclosed |