SCHEMBL16221826

Cc1cn([C@@H]2C[C@@H](OP(=O)(S)OC[C@@H]3CCC(n4cnc5c(=O)[nH]c(N)nc54)O3)[C@@H](COP(=O)(O)S)O2)c(=O)[nH]c1=O

nearest known ligand 0.55

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	F2	P00734	4/20	0.55

▸	TERT	O14746	1/20	0.51

▸	POLB	P06746	1/20	0.50

▸	TK1	P04183	3/20	0.48

▸	P2RY2	P41231	1/20	0.47

▸	P2RY4	P51582	1/20	0.47

▸	P2RY6	Q15077	1/20	0.47

▸	DTYMK	P23919	2/20	0.46

▸	FUT5	Q11128	1/20	0.44

▸	NT5E	P21589	1/20	0.44

▸	P2RY1	P47900	1/20	0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24239526	0.95	TERT (0.57)	F2TERTPOLBTK1P2RY2
SCHEMBL17151728	0.94	F2 (0.51)	F2TERTPOLBTK1P2RY2
SCHEMBL16221825	0.93	POLB (0.56)	F2POLBP2RY2P2RY4P2RY6
SCHEMBL27062478	0.93	F2 (0.52)	F2TERTPOLBTK1P2RY2
SCHEMBL18158912	0.92	POLB (0.50)	F2TERTPOLBP2RY2P2RY4
SCHEMBL16221824	0.92	POLB (0.50)	F2TERTPOLBP2RY2P2RY4
SCHEMBL18158887	0.90	DTYMK (0.58)	F2TERTPOLBTK1DTYMK
SCHEMBL24239532	0.90	DTYMK (0.58)	F2TERTPOLBTK1DTYMK
SCHEMBL18158882	0.90	DTYMK (0.58)	F2TERTPOLBTK1DTYMK
SCHEMBL16217855	0.88	TERT (0.50)	F2TERTPOLBP2RY2P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2014179625-A1	COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (a) EXPRESSION	ISIS PHARMACEUTICALS, INC. (US)	2014-11-06	—	—	WO	disclosed