Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bendroflumethiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 5/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CA2 | P00918 | 2/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bendroflumethiazide SCHEMBL26016 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ECYP3A4CYP1A2 | |
| Bendroflumethiazide SCHEMBL3359694 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ECYP3A4CYP1A2 | |
| Bendroflumethiazide SCHEMBL4427489 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ECYP3A4CYP1A2 | |
| Bendroflumethiazide SCHEMBL44537 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ECYP3A4CYP1A2 | |
| Bendroflumethiazide SCHEMBL6656036 | 0.83 | ALDH1A1 (0.66) | ALDH1A1LMNAKDM4ECYP3A4CYP1A2 | |
| Benzylhydrochlorothiazide SCHEMBL18314134 | 0.81 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ECYP3A4CYP1A2 | |
| Benzylhydrochlorothiazide SCHEMBL49671 | 0.81 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ECYP3A4CYP1A2 | |
| Bendroflumethiazide SCHEMBL28086384 | 0.81 | LMNA (0.85) | ALDH1A1LMNAKDM4ECYP3A4CYP1A2 | |
| Bendroflumetazide SCHEMBL29742733 | 0.79 | ALDH1A1 (0.86) | ALDH1A1LMNAKDM4ECYP3A4CYP1A2 | |
| Buthiazide SCHEMBL7357204 | 0.77 | TDP1 (0.61) | ALDH1A1LMNAKDM4ECYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9982042-B2 | Therapeutic combination and methods of treatment with a DLL4 antagonist and an anti-hypertensive agent | ONCOMED PHARMACEUTICALS, INC. (US) | 2018-05-29 | — | — | US | claimed |
| US-20170166632-A1 | Therapeutic Combination and Methods of Treatment With A DLL4 Antagonist and an Anti-Hypertensive Agent | ONCOMED PHARMACEUTICALS, INC. | 2017-06-15 | — | — | US | claimed |
| US-8883145-B2 | Methods of treatment with DLL4 antagonists and an anti-hypertensive agent | ONCOMED PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | claimed |