Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alpidem. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO known ✓ | P30536 | 3/20 | 0.73 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.78 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.78 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | ALB | P02768 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.73 |
| ▸ | DRD3 | P35462 | 1/20 | 0.73 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.73 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Saripidem SCHEMBL1061054 | 0.89 | GABRB2 (1.00) | GABRB2GABRA1GABRA5TSPONR1I2 | |
| Alpidem SCHEMBL122619 | 0.86 | TSPO (1.00) | GABRB2TSPONR1I2ABCB11ALB | |
| SCHEMBL23624269 | 0.82 | TSPO (0.88) | GABRB2TSPONR1I2ABCB11ALB | |
| Alpidem SCHEMBL8629259 | 0.82 | TSPO (0.71) | GABRB2TSPONR1I2ABCB11ALB | |
| SCHEMBL19444411 | 0.82 | TSPO (0.92) | GABRB2GABRA1TSPONR1I2ABCB11 | |
| SCHEMBL6642731 | 0.80 | TSPO (0.88) | GABRB2TSPONR1I2ABCB11ALB | |
| Alpidem SCHEMBL4014704 | 0.80 | TSPO (0.83) | GABRB2GABRA1TSPONR1I2ABCB11 | |
| SCHEMBL23624329 | 0.80 | TSPO (0.83) | GABRB2TSPONR1I2ABCB11ALB | |
| SCHEMBL23624249 | 0.80 | TSPO (0.86) | GABRB2TSPONR1I2ABCB11ALB | |
| SCHEMBL23624214 | 0.77 | TSPO (0.81) | GABRB2TSPONR1I2ABCB11ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9259477-B2 | GLP-1 receptor agonist peptide gastrin conjugates | ZEALAND PHARMA A/S (DK) | 2016-02-16 | — | — | US | disclosed |
| US-20140336107-A1 | GLP-1 RECEPTOR AGONIST PEPTIDE GASTRIN CONJUGATES | ZEALAND PHARMA A/S (DK) | 2014-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336107-A1 | GLP-1 RECEPTOR AGONIST PEPTIDE GASTRIN CONJUGATES | GLP1R, GIPR, GRPR | TSPO 496/4885GABRB2 384/4885GABRA1 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.