Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alpidem. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO known ✓ | P30536 | 4/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | ALB | P02768 | 1/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.71 |
| ▸ | DRD3 | P35462 | 1/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.69 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpidem SCHEMBL122619 | 0.84 | TSPO (1.00) | TSPONR1I2ABCB11ALBADORA3 | |
| Alpidem SCHEMBL16225062 | 0.82 | GABRB2 (0.78) | TSPONR1I2ABCB11ALBADORA3 | |
| SCHEMBL19444411 | 0.81 | TSPO (0.92) | TSPONR1I2ABCB11ALBADORA3 | |
| SCHEMBL23624269 | 0.79 | TSPO (0.88) | TSPONR1I2ABCB11ALBADORA3 | |
| SCHEMBL6642731 | 0.79 | TSPO (0.88) | TSPONR1I2ABCB11ALBADORA3 | |
| SCHEMBL23624249 | 0.78 | TSPO (0.86) | TSPONR1I2ABCB11ALBADORA3 | |
| Alpidem SCHEMBL4014704 | 0.77 | TSPO (0.83) | TSPONR1I2ABCB11ALBADORA3 | |
| SCHEMBL23624329 | 0.77 | TSPO (0.83) | TSPONR1I2ABCB11ALBADORA3 | |
| SCHEMBL23624214 | 0.76 | TSPO (0.81) | TSPONR1I2ABCB11ALBADORA3 | |
| SCHEMBL3035751 | 0.75 | TSPO (0.78) | TSPONR1I2ABCB11ALBADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819002-A1 | USE OF IMIDAZOL 1,2-a]PYRIDINE-3-ACETAMIDE DERIVATIVES FOR THE THERAPEUTIC TREATMENT OF NEUROPSYCHIATRIC SYNDROMES ASSOCIATED WITH DISFUNCTION OF THE NEURAL CIRCUITS OF THE BASAL GANGLIA | Clarendon-Trading & Investimentos LDA (PT) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031210-A1 | USE OF IMIDAZO[1,2-a]PYRIDINE-3-ACETAMIDE DERIVATIVES FOR THE THERAPEUTIC TREATMENT OF NEUROPSYCHIATRIC SYNDROMES ASSOCIATED WITH DISFUNCTION OF THE NEURAL CIRCUITS OF THE BASAL GANGLIA | CLARENDON-TRADING & INVESTIMENTOS LDA (PT) | 1996-10-10 | — | — | WO | disclosed |