Chrysoobtusin

Chrysoobtusin

SCHEMBL16226057

COc1cc2c(c(OC)c1OC)C(=O)c1c(cc(C)c(O)c1OC)C2=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EPHX2 P34913 5/20 1.00
▸ ELANE P08246 3/20 0.47
▸ PIM1 P11309 1/20 0.43
▸ ALDH1A1 P00352 3/20 0.42
▸ CYP3A4 P08684 2/20 0.42
▸ CYP1A2 P05177 1/20 0.42
▸ MAPT P10636 4/20 0.40
▸ KDM4E B2RXH2 3/20 0.40
▸ GLA P06280 2/20 0.40
▸ HPGD P15428 1/20 0.40
▸ ALOX15 P16050 1/20 0.40
▸ CCNB2 O95067 1/20 0.39
▸ CDK1 P06493 1/20 0.39
▸ CCNB1 P14635 1/20 0.39
▸ CCNB3 Q8WWL7 1/20 0.39
▸ LCK P06239 1/20 0.39
▸ THRB P10828 1/20 0.39
▸ LIMK1 P53667 1/20 0.39
▸ LIMK2 P53671 1/20 0.39
▸ NPC1 O15118 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16226676 0.93 EPHX2 (0.86) EPHX2ELANEPIM1ALDH1A1CYP3A4
SCHEMBL16226754 0.93 EPHX2 (1.00) EPHX2ELANEPIM1ALDH1A1CYP3A4
SCHEMBL31322006 0.93 EPHX2 (1.00) EPHX2ELANEPIM1ALDH1A1CYP3A4
SCHEMBL29396060 0.93 EPHX2 (1.00) EPHX2ELANEPIM1ALDH1A1CYP3A4
SCHEMBL16932396 0.90 EPHX2 (0.81) EPHX2ELANEPIM1ALDH1A1CYP3A4
SCHEMBL16226235 0.86 EPHX2 (0.76) EPHX2ELANEPIM1ALDH1A1MAPT
SCHEMBL28518188 0.85 EPHX2 (0.87) EPHX2ELANEPIM1ALDH1A1CYP3A4
SCHEMBL27927334 0.85 EPHX2 (0.86) EPHX2ELANEPIM1ALDH1A1CYP3A4
SCHEMBL29709334 0.85 EPHX2 (0.74) EPHX2ELANEPIM1ALDH1A1CYP3A4
SCHEMBL29709367 0.82 EPHX2 (0.70) EPHX2ELANEPIM1ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4714440-A2 A HEALING HERBAL-MINERAL COMPOSITION WITH ENHANCED EFFECTS Kurek, Janusz (PL) 2026-03-25 — — EP claimed
EP-4714440-A2 A HEALING HERBAL-MINERAL COMPOSITION WITH ENHANCED EFFECTS Kurek, Janusz (PL) 2026-03-25 — — EP disclosed
US-12507703-B2 Methods, devices and compositions for preserving human milk THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2025-12-30 — — US disclosed
US-20250169516-A1 METHODS, DEVICES AND COMPOSITIONS FOR PRESERVING HUMAN MILK THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2025-05-29 — — US disclosed
US-12239142-B2 Methods, devices and compositions for preserving human milk THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2025-03-04 — — US disclosed
US-20240268402-A1 Methods, Devices and Compositions for Preserving Human Milk THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2024-08-15 — — US disclosed
CN-118161568-A Composition and ointment formula for soothing liver and relieving depression as well as preparation method and application of composition and ointment formula 北京泰开尔营养科技发展有限责任公司 2024-06-11 — — CN disclosed
CN-103197018-B A kind of Yangxueqingnao granule anthraquinone component detection method TASLY PHARMACEUTICAL GROUP CO., LTD. (CN) 2016-04-13 — — CN disclosed
US-20140335050-A1 METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER THE GENERAL HOSPITAL CORPORATION (US) 2014-11-13 — — US disclosed
CN-103197018-A Yangxueqingnao granule anthraquinone component detection method TASLY PHARMACEUTICAL GROUP CO 2013-07-10 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140335050-A1 METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER IL2RA, CD74, IL2 EPHX2 2549/4885ELANE 2550/4885PIM1 4333/4885
US-12507703-B2 Methods, devices and compositions for preserving human milk LPL, CEL, LPO EPHX2 1252/4885ELANE 156/4885PIM1 1970/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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