Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 17/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.64 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17826589 | 0.88 | SIRT1 (0.60) | SIRT1SIRT2SIRT3 | |
| SCHEMBL16229386 | 0.87 | MEN1 (0.70) | SIRT1SIRT2SIRT3ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL1707568 | 0.87 | SIRT1 (0.82) | SIRT1SIRT2SIRT3 | |
| SCHEMBL4369732 | 0.86 | SIRT2 (0.64) | SIRT1SIRT2ALDH1A1SMN1; SMN2 | |
| SCHEMBL16229383 | 0.86 | SIRT2 (0.77) | SIRT1SIRT2SIRT3ALDH1A1 | |
| SCHEMBL16229469 | 0.86 | SIRT2 (0.73) | SIRT1SIRT2SIRT3ALDH1A1MAPT | |
| SCHEMBL16229381 | 0.86 | SIRT1 (0.67) | SIRT1SIRT2SIRT3ALDH1A1SMN1; SMN2 | |
| SCHEMBL16229390 | 0.85 | ALDH1A1 (0.70) | SIRT1SIRT2ALDH1A1SMN1; SMN2 | |
| SCHEMBL9539840 | 0.85 | SMN1; SMN2 (0.65) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL16229389 | 0.85 | SIRT2 (0.86) | SIRT1SIRT2SIRT3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440522-B1 | AROYLTHIOUREA AND ARYLTHIOCARBONYLUREA DERIVATIVES | UNIV DUNDEE (GB) | 2014-11-12 | — | — | EP | disclosed |