Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL90304 | 0.85 | DPP4 (0.35) | RENCYP1A2METAP2AKT1DPP4 | |
| SCHEMBL89518 | 0.85 | DPP4 (0.35) | RENCYP1A2METAP2AKT1DPP4 | |
| SCHEMBL8235325 | 0.81 | DPP4 (0.36) | METAP2AKT1DPP4 | |
| SCHEMBL90350 | 0.81 | DPP4 (0.36) | METAP2AKT1DPP4 | |
| SCHEMBL90271 | 0.81 | DPP4 (0.36) | METAP2AKT1DPP4 | |
| SCHEMBL7907019 | 0.80 | HSD17B10 (0.45) | RENHSD17B10CYP1A2METAP2HTT | |
| SCHEMBL13242434 | 0.75 | CYP1A2 (0.41) | RENCYP1A2METAP2DPP4ALDH1A1 | |
| SCHEMBL9076360 | 0.75 | CYP1A2 (0.41) | RENCYP1A2METAP2DPP4ALDH1A1 | |
| SCHEMBL12262018 | 0.74 | SHBG (0.41) | RENCYP1A2METAP2DPP4 | |
| SCHEMBL12262014 | 0.74 | SHBG (0.41) | RENCYP1A2METAP2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879607-B1 | HCV NS3 PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2014-11-12 | — | — | EP | disclosed |