Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7897551 | 0.93 | USP2 (0.47) | HSD17B10USP2HTTALDH1A1KMT2A | |
| SCHEMBL7897554 | 0.93 | USP2 (0.47) | HSD17B10USP2HTTALDH1A1KMT2A | |
| Butyl Alcohol SCHEMBL8589445 | 0.87 | USP2 (0.46) | HSD17B10USP2HTTALDH1A1KMT2A | |
| SCHEMBL7897780 | 0.83 | SMN1; SMN2 (0.33) | USP2 | |
| SCHEMBL7897784 | 0.83 | SMN1; SMN2 (0.33) | USP2 | |
| SCHEMBL16229648 | 0.80 | REN (0.35) | HSD17B10HTTTDP1ALDH1A1KMT2A | |
| SCHEMBL13500027 | 0.78 | CYP1A2 (0.41) | HSD17B10USP2HTTCYP1A2METAP2 | |
| SCHEMBL13500021 | 0.76 | CYP1A2 (0.48) | HSD17B10USP2HTTCYP1A2LPAR5 | |
| SCHEMBL14402446 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KMT2ACYP1A2RENMETAP2 | |
| SCHEMBL19215714 | 0.76 | MEN1 (0.33) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |
| WO-1998050031-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |