Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 2/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89518 | 1.00 | DPP4 (0.35) | DPP4AKT1METAP2CYP1A2REN | |
| SCHEMBL16229648 | 0.85 | REN (0.35) | DPP4AKT1METAP2CYP1A2REN | |
| SCHEMBL90350 | 0.80 | DPP4 (0.36) | DPP4AKT1METAP2SLC1A3SLC1A2 | |
| SCHEMBL8235325 | 0.80 | DPP4 (0.36) | DPP4AKT1METAP2SLC1A3SLC1A2 | |
| SCHEMBL90271 | 0.80 | DPP4 (0.36) | DPP4AKT1METAP2SLC1A3SLC1A2 | |
| SCHEMBL13889045 | 0.78 | CYP1A2 (0.34) | CYP1A2 | |
| SCHEMBL1911130 | 0.78 | CYP1A2 (0.34) | CYP1A2 | |
| SCHEMBL12262014 | 0.77 | SHBG (0.41) | DPP4METAP2CYP1A2REN | |
| SCHEMBL12631699 | 0.77 | SHBG (0.41) | DPP4METAP2CYP1A2REN | |
| SCHEMBL12262018 | 0.77 | SHBG (0.41) | DPP4METAP2CYP1A2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192148-A1 | Organic Compounds | REN, ACE, AGTR1 | DPP4 436/4885AKT1 4747/4885METAP2 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.