Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL90350 | 1.00 | DPP4 (0.36) | DPP4AKT1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL90271 | 1.00 | DPP4 (0.36) | DPP4AKT1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL16229648 | 0.81 | REN (0.35) | DPP4AKT1METAP2 | |
| SCHEMBL89518 | 0.80 | DPP4 (0.35) | DPP4AKT1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL90304 | 0.80 | DPP4 (0.35) | DPP4AKT1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL10305516 | 0.79 | DPP4 (0.43) | DPP4METAP1 | |
| SCHEMBL16824140 | 0.78 | CTSK (0.33) | CTSK | |
| SCHEMBL12849238 | 0.77 | CTSK (0.36) | CTSK | |
| SCHEMBL1911353 | 0.77 | CTSK (0.36) | CTSK | |
| SCHEMBL14152515 | 0.76 | ANPEP (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |