Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784625 | 0.92 | SLC6A9 (0.39) | SLC6A9KCNH2ADRA1AADRA1BHTR6 | |
| SCHEMBL16784624 | 0.92 | SLC6A9 (0.46) | SLC6A9KCNH2ADRA1AADRA1B | |
| SCHEMBL16229787 | 0.90 | SLC6A9 (0.39) | SLC6A9KCNH2HTR6 | |
| SCHEMBL16229805 | 0.89 | SLC6A9 (0.38) | SLC6A9KCNH2ADRA1AADRA1BF10 | |
| SCHEMBL16784655 | 0.87 | SLC6A9 (0.50) | SLC6A9KCNH2 | |
| SCHEMBL16229756 | 0.87 | SLC6A9 (0.32) | SLC6A9KCNH2 | |
| SCHEMBL16229764 | 0.85 | KMT2A (0.32) | SLC6A9 | |
| SCHEMBL16229757 | 0.85 | SLC6A9 (0.43) | SLC6A9ADRA1AADRA1BHTR6HTR1A | |
| SCHEMBL16229770 | 0.84 | SLC6A9 (0.53) | SLC6A9KCNH2 | |
| SCHEMBL16229807 | 0.83 | SLC6A9 (0.36) | SLC6A9KCNH2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |