Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 4/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229799 | 0.92 | SLC6A9 (0.33) | SLC6A9KCNH2 | |
| SCHEMBL16229764 | 0.92 | KMT2A (0.32) | SLC6A9OPRL1RORC | |
| SCHEMBL16229782 | 0.91 | SLC6A9 (0.39) | SLC6A9KCNH2ALDH1A1 | |
| SCHEMBL16229802 | 0.89 | GALR3 (0.38) | SLC6A9 | |
| SCHEMBL16229807 | 0.88 | SLC6A9 (0.36) | SLC6A9TBXA2RKCNH2EPHX2ALDH1A1 | |
| SCHEMBL16229769 | 0.88 | DPP4 (0.34) | SLC6A9RORC | |
| SCHEMBL16229765 | 0.87 | SLC6A9 (0.38) | SLC6A9KCNH2 | |
| SCHEMBL16229762 | 0.84 | KMT2A (0.32) | SLC6A9 | |
| SCHEMBL16229761 | 0.83 | SLC6A9 (0.37) | SLC6A9TBXA2RALDH1A1AKR1C3 | |
| SCHEMBL16784656 | 0.83 | SLC6A9 (0.35) | SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |