Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 5/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.31 |
| ▸ | AXL | P30530 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784625 | 0.91 | SLC6A9 (0.39) | SLC6A9KCNH2HTR6SCN9A | |
| SCHEMBL16784624 | 0.90 | SLC6A9 (0.46) | SLC6A9KCNH2SCN9A | |
| SCHEMBL16229765 | 0.90 | SLC6A9 (0.38) | SLC6A9KCNH2HTR6 | |
| SCHEMBL16229812 | 0.89 | SLC6A9 (0.39) | SLC6A9GALR3HTR6TRPV4NPSR1 | |
| SCHEMBL16229781 | 0.88 | SLC6A9 (0.49) | SLC6A9GALR3KCNH2 | |
| SCHEMBL16229802 | 0.87 | GALR3 (0.38) | SLC6A9GALR3TRPV4CARM1PRMT6 | |
| SCHEMBL16784643 | 0.86 | GALR3 (0.43) | SLC6A9GALR3TRPV4CARM1PRMT6 | |
| SCHEMBL16784648 | 0.85 | SLC6A9 (0.42) | SLC6A9GALR3HTR6AXLTYRO3 | |
| SCHEMBL16229791 | 0.84 | SLC6A9 (0.55) | SLC6A9KCNH2L3MBTL1 | |
| SCHEMBL16229808 | 0.84 | GALR3 (0.42) | SLC6A9GALR3KCNH2TRPV4CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |