Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 4/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 6/20 | 0.33 |
| ▸ | HTR7 | P34969 | 6/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229753 | 0.92 | SLC6A9 (0.41) | SLC6A9AXLMERTKHTR6ALK | |
| SCHEMBL16784640 | 0.91 | SLC6A9 (0.41) | SLC6A9HTR6HTR1AHTR7HTR2A | |
| SCHEMBL16229757 | 0.90 | SLC6A9 (0.43) | SLC6A9HTR6HTR1AHTR7DRD2 | |
| SCHEMBL16784632 | 0.90 | SLC6A9 (0.52) | SLC6A9AXLTYRO3MERTKHTR6 | |
| SCHEMBL16229800 | 0.89 | SLC6A9 (0.36) | SLC6A9AXLTYRO3MERTKHTR6 | |
| SCHEMBL16229791 | 0.88 | SLC6A9 (0.55) | SLC6A9 | |
| SCHEMBL16229772 | 0.87 | AXL (0.37) | SLC6A9AXLTYRO3MERTKALK | |
| SCHEMBL16229812 | 0.86 | SLC6A9 (0.39) | SLC6A9AXLTYRO3MERTKHTR6 | |
| SCHEMBL16229787 | 0.85 | SLC6A9 (0.39) | SLC6A9AXLTYRO3MERTKHTR6 | |
| SCHEMBL16229810 | 0.85 | SLC6A9 (0.38) | SLC6A9AXLTYRO3MERTKHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |