Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15196742 | 0.85 | KCNJ1 (0.44) | NOTUMKCNJ1ALDH1A1MAPTHPGD | |
| SCHEMBL28114782 | 0.73 | L3MBTL1 (0.39) | ALDH1A1MAPTTSHRMAPK1POLB | |
| SCHEMBL18213684 | 0.71 | KCNJ1 (0.58) | NOTUMKCNJ1KMT2AF2ALDH1A1 | |
| SCHEMBL18216598 | 0.68 | NOTUM (0.45) | NOTUMKCNJ1KMT2AALDH1A1MAPT | |
| SCHEMBL16232247 | 0.67 | KCNJ1 (0.38) | KCNJ1POLBBLMTDP1 | |
| SCHEMBL15017919 | 0.63 | ALDH1A1 (0.46) | KCNJ1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL15018160 | 0.63 | AGBL2 (0.51) | NOTUMKCNJ1KMT2AALDH1A1MAPT | |
| SCHEMBL14242835 | 0.62 | NOTUM (0.66) | NOTUMKCNJ1F2ALDH1A1MAPT | |
| SCHEMBL16232248 | 0.62 | KCNJ1 (0.42) | NOTUMKCNJ1KMT2AALDH1A1MAPT | |
| SCHEMBL16867052 | 0.62 | NOTUM (0.45) | NOTUMKCNJ1ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206199-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2015-12-08 | — | — | US | disclosed |
| US-20140336177-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2014-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336177-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ11, KCNJ1, KCNJ2 | NOTUM 4002/4885KCNJ1 2/4885MEN1 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.