Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT2 | O60551 | 1/20 | 0.53 |
| ▸ | NMT1 | P30419 | 1/20 | 0.53 |
| ▸ | FURIN | P09958 | 8/20 | 0.48 |
| ▸ | PCSK6 | P29122 | 1/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | HPN | P05981 | 1/20 | 0.47 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.47 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16259323 | 1.00 | NMT2 (0.53) | NMT2NMT1FURINPCSK6SIRT6 | |
| SCHEMBL16234712 | 1.00 | NMT2 (0.53) | NMT2NMT1FURINPCSK6SIRT6 | |
| SCHEMBL16234715 | 1.00 | NMT2 (0.53) | NMT2NMT1FURINPCSK6SIRT6 | |
| SCHEMBL16259360 | 1.00 | NMT2 (0.53) | NMT2NMT1FURINPCSK6SIRT6 | |
| SCHEMBL16259340 | 1.00 | NMT2 (0.53) | NMT2NMT1FURINPCSK6SIRT6 | |
| SCHEMBL16234693 | 1.00 | NMT2 (0.53) | NMT2NMT1FURINPCSK6SIRT6 | |
| SCHEMBL16507920 | 0.95 | FURIN (0.51) | NMT2NMT1FURINPCSK6SIRT6 | |
| SCHEMBL20965523 | 0.95 | SIRT6 (0.52) | NMT2NMT1FURINPCSK6SIRT6 | |
| SCHEMBL20965281 | 0.91 | FURIN (0.48) | NMT2NMT1FURINPCSK6SIRT6 | |
| SCHEMBL20951745 | 0.89 | FURIN (0.52) | NMT2NMT1FURINPCSK6SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353149-B2 | Compounds, compositions and methods for the treatment of diseases through inhibiting TGF-β activity | SOUTHERN RESEARCH INSTITUTE (US) | 2016-05-31 | — | — | US | disclosed |
| US-9353149-B2 | Compounds, compositions and methods for the treatment of diseases through inhibiting TGF-β activity | SOUTHERN RESEARCH INSTITUTE (US) | 2016-05-31 | — | — | US | disclosed |
| US-20140336115-A1 | Compounds, Compositions and Methods for the Treatment of Diseases Through Inhibiting TGF-ß Activity | SOUTHERN RESEARCH INSTITUTE (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336115-A1 | Compounds, Compositions and Methods for the Treatment of Diseases Through Inhibiting TGF-ß Activity | SOUTHERN RESEARCH INSTITUTE (US) | 2014-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336115-A1 | Compounds, Compositions and Methods for the Treatment of Diseases Through Inhibiting TGF-ß Activity | TGFB1, TGFB2, TGFBR1 | NMT2 789/4885NMT1 714/4885FURIN 2056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.