Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235564 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2AMEP1BHTTALDH1A1 | |
| SCHEMBL16235080 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AHTTALDH1A1GAA | |
| SCHEMBL16235287 | 0.72 | RAB9A (0.38) | SMN1; SMN2KMT2AHTTALDH1A1KDM4E | |
| SCHEMBL15464777 | 0.71 | TP53 (0.62) | SMN1; SMN2KMT2AMEP1BHTTALDH1A1 | |
| SCHEMBL16235221 | 0.69 | CYP17A1 (0.36) | SMN1; SMN2KMT2AHTTALDH1A1KDM4E | |
| SCHEMBL2005565 | 0.67 | SMN1; SMN2 (0.65) | SMN1; SMN2KMT2AHTTALDH1A1KDM4E | |
| SCHEMBL16235225 | 0.66 | KMT2A (0.33) | KMT2AHTTALDH1A1MAPTMEN1 | |
| SCHEMBL4454747 | 0.66 | ALDH1A1 (0.68) | SMN1; SMN2KMT2AMEP1BHTTALDH1A1 | |
| SCHEMBL22233994 | 0.65 | KMT2A (0.57) | SMN1; SMN2KMT2AHTTKDM4EGAA | |
| SCHEMBL16235440 | 0.65 | RAB9A (0.40) | SMN1; SMN2HTTGAALMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |