Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | WRN | Q14191 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16237501 | 0.86 | RAB9A (0.48) | PLA2G7NPC1RAB9AMAPTTHRB | |
| SCHEMBL16236610 | 0.85 | NPC1 (0.49) | PLA2G7NPC1RAB9AMAPTTHRB | |
| SCHEMBL16237029 | 0.82 | CYP1A2 (0.41) | PLA2G7NPC1RAB9AMAPTTHRB | |
| SCHEMBL16237067 | 0.81 | GRM4 (0.41) | GRM4PLA2G7NPC1RAB9AMAPT | |
| SCHEMBL16237311 | 0.80 | GRM4 (0.49) | GRM4NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL16237050 | 0.79 | PLA2G7 (0.37) | PLA2G7 | |
| SCHEMBL16237215 | 0.79 | CYP1A2 (0.45) | PLA2G7NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL16236529 | 0.79 | IDO1 (0.43) | GRM4NPC1RAB9AMAPK1AKT1 | |
| SCHEMBL21623094 | 0.78 | GRM4 (0.55) | GRM4MAPTMAPK1ALDH1A1MEN1 | |
| SCHEMBL16236925 | 0.76 | CYP1A2 (0.36) | PLA2G7NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997011-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2016-03-23 | — | — | EP | disclosed |
| WO-2014184350-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN R&D IRELAND (IE) | 2014-11-20 | — | — | WO | disclosed |