Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 3/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16237501 | 0.84 | RAB9A (0.48) | KDM4EMEN1LMNAMAPK1KMT2A | |
| SCHEMBL16237067 | 0.84 | GRM4 (0.41) | KDM4EMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL16236610 | 0.83 | NPC1 (0.49) | IDO1TDO2KDM4EMEN1MAPK1 | |
| SCHEMBL16237029 | 0.81 | CYP1A2 (0.41) | KDM4EMEN1LMNAMAPK1KMT2A | |
| SCHEMBL16237208 | 0.79 | GRM4 (0.50) | KDM4EMEN1MAPK1KMT2AGRM4 | |
| SCHEMBL16237215 | 0.77 | CYP1A2 (0.45) | KDM4ENPC1ALDH1A1PRNPGAA | |
| SCHEMBL16236925 | 0.74 | CYP1A2 (0.36) | KDM4EMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL10116449 | 0.74 | LMNA (0.48) | EPHX2MEN1LMNAMAPK1KMT2A | |
| SCHEMBL16236340 | 0.74 | ENPP2 (0.43) | MEN1KMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL16236530 | 0.74 | TP53 (0.48) | EPHX2MEN1LMNAKMT2ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997011-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2016-03-23 | — | — | EP | disclosed |
| WO-2014184350-A1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN R&D IRELAND (IE) | 2014-11-20 | — | — | WO | disclosed |