SCHEMBL16239113

SCHEMBL16239113

O=C1CC(=O)N(c2ccc(NC(=O)c3ncccc3Cl)cc2)c2ccc3c(c2N1)CCCC3

nearest known ligand 0.51

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
P2RX4 Q99571 9/20 0.51
GRM1 Q13255 3/20 0.43
GRM4 Q14833 8/20 0.40
CYP2C9 P11712 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16239015 0.85 P2RX4 (0.48) P2RX4
SCHEMBL16239155 0.85 P2RX4 (0.53) P2RX4
SCHEMBL16239092 0.83 P2RX4 (0.68) P2RX4
SCHEMBL30297218 0.83 P2RX4 (0.68) P2RX4
SCHEMBL16267380 0.81 P2RX4 (0.48) P2RX4
SCHEMBL16238993 0.80 P2RX4 (0.51) P2RX4
SCHEMBL16239101 0.79 P2RX4 (0.51) P2RX4
SCHEMBL16239011 0.79 P2RX4 (0.49) P2RX4
SCHEMBL30297415 0.78 MAPT (0.45) P2RX4
SCHEMBL16238963 0.78 MAPT (0.45) P2RX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11918589-B2 Medicament for treatment of multiple sclerosis NIPPON CHEMIPHAR CO., LTD. (JP) 2024-03-05 US claimed
WO-2023190826-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR SUPPRESSING OR TREATING SYMPTOMS ACCOMPANYING PSEUDO-ALLERGIC REACTIONS 学校法人 高崎健康福祉大学 2023-10-05 WO claimed
US-20230277552-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH ALLERGIC REACTION NIPPON CHEMIPHAR CO., LTD. (JP) 2023-09-07 US claimed
WO-2023157895-A1 PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR ENDOMETRIOSIS OR ADENOMYOSIS 国立大学法人 鳥取大学 2023-08-24 WO claimed
EP-4190356-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOMS ASSOCIATED WITH ALLERGIC REACTION Nippon Chemiphar Co., Ltd. (JP) 2023-06-07 EP claimed
US-20230149421-A1 MEDICAMENT FOR PREVENTING OR TREATING IRRITABLE BOWEL SYNDROME OR INFLAMMATORY BOWEL DISEASE NIPPON CHEMIPHAR CO., LTD. (JP) 2023-05-18 US claimed
WO-2023054578-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR RESPIRATORY DISEASES 日本ケミファ株式会社 2023-04-06 WO claimed
EP-4129296-A1 DRUG FOR PREVENTION OR TREATMENT OF IRRITABLE BOWEL SYNDROME OR INFLAMMATORY BOWEL DISEASE Università di Pisa (IT) 2023-02-08 EP claimed
EP-3848051-A1 MEDICINE FOR DIABETIC PERIPHERAL NEUROPATHY Nippon Chemiphar Co., Ltd. (JP) 2021-07-14 EP claimed
US-20210121478-A1 MEDICAMENT FOR TREATMENT OF MULTIPLE SCLEROSIS NIPPON CHEMIPHAR CO., LTD. (JP) 2021-04-29 US claimed
US-20200223806-A1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO., LTD (JP) 2020-07-16 US claimed
EP-2803662-B1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO (JP) 2017-03-01 EP claimed
US-9382236-B2 P2X4 receptor antagonist NIPPON CHEMIPHAR CO., LTD (JP) 2016-07-05 US claimed
US-11918589-B2 Medicament for treatment of multiple sclerosis NIPPON CHEMIPHAR CO., LTD. (JP) 2024-03-05 US disclosed
WO-2023190826-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR SUPPRESSING OR TREATING SYMPTOMS ACCOMPANYING PSEUDO-ALLERGIC REACTIONS 学校法人 高崎健康福祉大学 2023-10-05 WO disclosed
US-20230277552-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH ALLERGIC REACTION NIPPON CHEMIPHAR CO., LTD. (JP) 2023-09-07 US disclosed
US-20160280667-A1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO., LTD (JP) 2016-09-29 US disclosed
US-9382236-B2 P2X4 receptor antagonist NIPPON CHEMIPHAR CO., LTD (JP) 2016-07-05 US disclosed
US-20140357858-A1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO., LTD (JP) 2014-12-04 US disclosed
EP-2803662-A1 P2X4 RECEPTOR ANTAGONIST Nippon Chemiphar Co., Ltd. (JP) 2014-11-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210121478-A1 MEDICAMENT FOR TREATMENT OF MULTIPLE SCLEROSIS TRPM4, TRPM7, P2RX3 P2RX4 5/4885GRM1 158/4885GRM4 77/4885
US-20160280667-A1 P2X4 RECEPTOR ANTAGONIST P2RX7, P2RX1, P2RX2 P2RX4 6/4885GRM1 110/4885GRM4 187/4885
US-20140357858-A1 P2X4 RECEPTOR ANTAGONIST P2RX7, P2RX1, P2RX2 P2RX4 6/4885GRM1 116/4885GRM4 186/4885
US-20200223806-A1 P2X4 RECEPTOR ANTAGONIST P2RX7, P2RX1, P2RX2 P2RX4 6/4885GRM1 116/4885GRM4 186/4885
US-11918589-B2 Medicament for treatment of multiple sclerosis P2RX3, TRPM4, P2RX4 P2RX4 3/4885GRM1 131/4885GRM4 69/4885
US-20230277552-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH ALLERGIC REACTION P2RX5, P2RX3, P2RX2 P2RX4 4/4885GRM1 648/4885GRM4 513/4885
US-20230149421-A1 MEDICAMENT FOR PREVENTING OR TREATING IRRITABLE BOWEL SYNDROME OR INFLAMMATORY BOWEL DISEASE P2RX5, P2RX3, P2RX2 P2RX4 5/4885GRM1 233/4885GRM4 145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.