Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.38 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.38 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.38 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | DDX3X | O00571 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239649 | 0.92 | KMT2A (0.41) | KMT2ADDX3XGAAMEN1CYP1A2 | |
| SCHEMBL16239499 | 0.91 | KMT2A (0.41) | MOGAT2KMT2AGAAMEN1TSHR | |
| SCHEMBL16239852 | 0.87 | SLC10A2 (0.39) | SLC10A2SLC10A1SLC10A6KMT2AGAA | |
| SCHEMBL16239817 | 0.85 | SLC22A12 (0.47) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2137469 | 0.83 | MEN1 (0.40) | SLC10A2SLC10A1SLC10A6MOGAT2KMT2A | |
| SCHEMBL2135449 | 0.80 | SLC10A2 (0.46) | SLC10A2SLC10A1SLC10A6KMT2AGAA | |
| SCHEMBL2138437 | 0.79 | CCR1 (0.41) | SLC10A2SLC10A1SLC10A6CYP3A4POLB | |
| SCHEMBL16239807 | 0.79 | FFAR4 (0.45) | KMT2AGAAMEN1SLC22A12LMNA | |
| SCHEMBL16239957 | 0.78 | MCOLN2 (0.39) | KMT2ATSHRLMNANPSR1SLC40A1 | |
| SCHEMBL16239801 | 0.78 | MEN1 (0.50) | KMT2AGAAMEN1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630124-B1 | TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | claimed |