Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16240086 | 0.93 | FFAR4 (0.48) | FFAR4FFAR1CDK1CCNB1CCNA2 | |
| SCHEMBL16239799 | 0.93 | FFAR4 (0.45) | FFAR4GAAFFAR1CDK1CCNB1 | |
| SCHEMBL16239667 | 0.89 | KIF11 (0.40) | ALDH1A1LMNASMN1; SMN2KDM1A | |
| SCHEMBL16240123 | 0.88 | SLC22A12 (0.43) | ALDH1A1SLC22A12 | |
| SCHEMBL16239486 | 0.86 | HPGD (0.43) | GAAHPGDCA12CA1CA2 | |
| SCHEMBL16239526 | 0.85 | GAA (0.42) | GAAHPGDCA12CA1CA2 | |
| SCHEMBL16239989 | 0.83 | IMPDH2 (0.40) | GAAHPGDCA12CA1CA2 | |
| SCHEMBL16239649 | 0.83 | KMT2A (0.41) | FFAR4GAAHTR6ALDH1A1SMN1; SMN2 | |
| SCHEMBL2136176 | 0.82 | PKM (0.46) | FFAR4GAAHPGDFFAR1CDK1 | |
| SCHEMBL16240075 | 0.79 | L3MBTL1 (0.45) | GAAHPGDALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630124-B1 | TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | claimed |