Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.35 |
| ▸ | DDX3X | O00571 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239499 | 0.93 | KMT2A (0.41) | KMT2AGAAFFAR4MEN1TSHR | |
| SCHEMBL16239491 | 0.92 | SLC10A2 (0.38) | KMT2AGAASLC40A1MEN1CYP1A2 | |
| SCHEMBL16239817 | 0.88 | SLC22A12 (0.47) | KMT2ASLC40A1MEN1CYP1A2CYP3A4 | |
| SCHEMBL16239957 | 0.86 | MCOLN2 (0.39) | KMT2ASLC40A1TSHRMCOLN2MCOLN3 | |
| SCHEMBL16240077 | 0.85 | TSHR (0.38) | KMT2AGAASLC40A1HTR6MEN1 | |
| SCHEMBL16239807 | 0.83 | FFAR4 (0.45) | KMT2AGAAFFAR4HTR6MEN1 | |
| SCHEMBL16239675 | 0.82 | HTR6 (0.35) | SLC40A1HTR6MCOLN2MCOLN3MCOLN1 | |
| SCHEMBL16239801 | 0.80 | MEN1 (0.50) | KMT2AGAAMEN1TSHRMCOLN3 | |
| SCHEMBL2135223 | 0.80 | LMNA (0.42) | KMT2AGAASLC40A1MEN1ALDH1A1 | |
| SCHEMBL16239852 | 0.78 | SLC10A2 (0.39) | KMT2AGAAMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630124-B1 | TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | claimed |