Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364169 | 0.83 | HSD17B10 (0.37) | ALOX15ALOX12ESR1ESR2TDP1 | |
| SCHEMBL27321635 | 0.75 | HSD17B10 (0.37) | ESR1TDP1L3MBTL1 | |
| SCHEMBL17057374 | 0.71 | HSD17B10 (0.37) | TDP1L3MBTL1 | |
| SCHEMBL15577467 | 0.68 | HSD17B10 (0.34) | TDP1L3MBTL1 | |
| SCHEMBL21786709 | 0.66 | AGBL2 (0.38) | TDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL23998926 | 0.65 | CRHR1 (0.37) | TDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL15577466 | 0.65 | MAPK1 (0.36) | ESR1MEN1KMT2A | |
| SCHEMBL15543565 | 0.65 | MAPK1 (0.36) | — | |
| SCHEMBL365208 | 0.63 | SCN9A (0.47) | — | |
| SCHEMBL16175295 | 0.63 | MAPK1 (0.33) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593431-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |