Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.50 |
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 2/20 | 0.48 |
| ▸ | RXRG | P48443 | 2/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16240249 | 0.89 | RXRA (0.63) | LRRK2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL16240247 | 0.86 | MRGPRX4 (0.55) | LRRK2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL1104996 | 0.82 | LRRK2 (0.61) | LRRK2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL1101410 | 0.78 | LRRK2 (0.53) | LRRK2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL1104997 | 0.76 | SCN9A (0.48) | CYP2C9CYP3A4FPR2SCN9APTGDR2 | |
| SCHEMBL1138889 | 0.76 | MRGPRX4 (0.55) | MRGPRX4RXRARXRBRXRGCYP2C9 | |
| SCHEMBL1753432 | 0.75 | PTGDR2 (0.74) | PTGDR2 | |
| SCHEMBL5099944 | 0.74 | PTGER1 (0.52) | LRRK2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL509652 | 0.72 | MAOB (0.74) | MRGPRX4RXRARXRBMAPTSMN1; SMN2 | |
| SCHEMBL6709526 | 0.72 | MAOB (0.74) | MRGPRX4RXRARXRBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593428-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |