Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.63 |
| ▸ | RXRB | P28702 | 5/20 | 0.63 |
| ▸ | RXRG | P48443 | 5/20 | 0.63 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 8/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239759 | 0.89 | LRRK2 (0.51) | RXRARXRBRXRGPTGER1CYP2C9 | |
| SCHEMBL1104996 | 0.88 | LRRK2 (0.61) | RXRARXRBRXRGPTGER1CYP2C9 | |
| SCHEMBL16240247 | 0.85 | MRGPRX4 (0.55) | RXRARXRBRXRGPTGER1CYP2C9 | |
| SCHEMBL1101410 | 0.80 | LRRK2 (0.53) | RXRARXRBRXRGPTGER1CYP2C9 | |
| SCHEMBL19951274 | 0.78 | RXRA (0.76) | RXRARXRBRXRGMRGPRX4NR4A2 | |
| SCHEMBL1690401 | 0.74 | PTGDR2 (0.78) | RXRARXRBRXRGPTGDR2 | |
| SCHEMBL1104997 | 0.73 | SCN9A (0.48) | CYP2C9PTGDR2 | |
| SCHEMBL4426012 | 0.73 | RXRA (0.68) | RXRARXRBRXRGPTGER1MRGPRX4 | |
| SCHEMBL5102994 | 0.72 | PTGER1 (0.66) | RXRARXRBRXRGPTGER1CYP2C9 | |
| SCHEMBL4923018 | 0.72 | PTGER1 (0.96) | RXRARXRBRXRGPTGER1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593428-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |