Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 7/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | LIPE | Q05469 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1104996 | 0.92 | LRRK2 (0.61) | LRRK2PTGER1CYP2C9PTGDR2RXRA | |
| SCHEMBL29952290 | 0.84 | LIPE (0.60) | LRRK2PTGER1LIPERXRARXRB | |
| SCHEMBL1950920 | 0.84 | LIPE (0.60) | LRRK2PTGER1LIPERXRARXRB | |
| SCHEMBL16240249 | 0.80 | RXRA (0.63) | LRRK2PTGER1CYP2C9PTGDR2RXRA | |
| SCHEMBL16239759 | 0.78 | LRRK2 (0.51) | LRRK2PTGER1CYP2C9PTGDR2RXRA | |
| SCHEMBL16635189 | 0.75 | LIPE (0.60) | LRRK2PTGER1LIPERXRARXRB | |
| SCHEMBL31043388 | 0.75 | LIPE (0.60) | LRRK2PTGER1LIPERXRARXRB | |
| SCHEMBL16240247 | 0.75 | MRGPRX4 (0.55) | LRRK2PTGER1CYP2C9PTGDR2RXRA | |
| SCHEMBL4884284 | 0.74 | LRRK2 (0.54) | LRRK2PTGER1LIPERXRARXRB | |
| SCHEMBL1104997 | 0.73 | SCN9A (0.48) | CYP2C9PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153814-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2012-04-10 | — | — | US | disclosed |