Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.31 |
| ▸ | KDR | P35968 | 3/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.31 |
| ▸ | LPL | P06858 | 2/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16175379 | 0.87 | AAK1 (0.41) | AAK1GSK3AGSK3BEGFRPDGFRB | |
| SCHEMBL19399964 | 0.79 | GSK3A (0.39) | AAK1GSK3AGSK3BEGFRPDGFRB | |
| SCHEMBL2067944 | 0.78 | AAK1 (0.38) | AAK1GSK3AGSK3BEGFRPDGFRB | |
| SCHEMBL30988760 | 0.73 | LPL (0.41) | AAK1GSK3AGSK3BEGFRPDGFRB | |
| SCHEMBL10380169 | 0.73 | LPL (0.41) | AAK1GSK3AGSK3BEGFRPDGFRB | |
| SCHEMBL16175400 | 0.73 | AAK1 (0.47) | AAK1GSK3AGSK3BEGFRPDGFRB | |
| SCHEMBL15555994 | 0.73 | DGAT1 (0.37) | AAK1GSK3AGSK3BEGFRPDGFRB | |
| SCHEMBL16175121 | 0.72 | AAK1 (0.46) | AAK1GSK3AGSK3BEGFRPDGFRB | |
| SCHEMBL16239554 | 0.72 | ALOX15 (0.35) | ESR2 | |
| SCHEMBL9948119 | 0.71 | GSK3A (0.36) | AAK1GSK3AGSK3BEGFRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593431-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |