Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | LDHA | P00338 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2073200 | 0.88 | MCHR1 (0.56) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL5798843 | 0.83 | RAB9A (0.65) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL28983104 | 0.82 | CHRM5 (0.73) | MAPTSMN1; SMN2CHRM5LMNAALDH1A1 | |
| SCHEMBL28983145 | 0.82 | CHRM5 (0.73) | MAPTSMN1; SMN2CHRM5LMNAALDH1A1 | |
| SCHEMBL4011536 | 0.81 | LDHA (0.78) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL28983152 | 0.81 | CHRM5 (0.72) | MAPTKDM4ESMN1; SMN2CHRM5LMNA | |
| SCHEMBL28983186 | 0.81 | CHRM5 (0.71) | MAPTSMN1; SMN2CHRM5LMNAALDH1A1 | |
| SCHEMBL28983188 | 0.81 | CHRM5 (0.71) | MAPTSMN1; SMN2CHRM5L3MBTL1LMNA | |
| SCHEMBL28983123 | 0.80 | ALDH1A1 (0.86) | NPC1RAB9AMAPTSMN1; SMN2CHRM5 | |
| SCHEMBL28983167 | 0.80 | CHRM5 (0.62) | MAPTSMN1; SMN2CHRM5LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8981086-B2 | Phosphine-ligated palladium sulfonate palladacycles | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-03-17 | — | — | US | disclosed |
| US-20150045570-A1 | PHOSPHINE-LIGATED PALLADIUM SULFONATE PALLADACYCLES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-12 | — | — | US | disclosed |
| US-8889857-B2 | Phosphine-ligated palladium sulfonate palladacycles | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045570-A1 | PHOSPHINE-LIGATED PALLADIUM SULFONATE PALLADACYCLES | PHOSPHO1, PDCD1, PDCD1LG2 | NPC1 4689/4885RAB9A 474/4885MAPT 3732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.